Best answer: Yes. While there will be some returning characters who you’ll recognize from playing previous Borderlands games, and there will likely be references to past events, you’ll still be able to follow the plot without playing other franchise entries. The game brings new villains, a new plot, and a new set of Vault Hunters.
Can I jump into Borderlands 3 without touching past games?
Yes, you’ll be fine. While past characters like Lilith or Rhys will be making appearances, you don’t have to go back and play all the earlier games. Events that happened previously will be referenced, but this is a new plot, with new main characters, new villains, and a new storyline.